Evaluation of aztreonam in experimental bacterial meningitis and cerebritis

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Evaluation of aztreonam in experimental bacterial meningitis and cerebritis.

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Penetration of aztreonam into cerebrospinal fluid of patients with bacterial meningitis.

The penetration of aztreonam into the cerebrospinal fluid was determined in 16 patients with bacterial meningitis undergoing treatment with other antibiotics. Three aztreonam doses of 30 mg/kg were infused intravenously over 30 to 45 min at 8-h intervals, first between days 2 and 4 and again between days 11 and 20 after onset of the disease. Concentrations of aztreonam in serum and cerebrospina...

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ژورنال

عنوان ژورنال: Antimicrobial Agents and Chemotherapy

سال: 1983

ISSN: 0066-4804,1098-6596

DOI: 10.1128/aac.24.5.682